Use of Genetic Variation as Biomarkers for Alzheimer's Disease
Identifieur interne : 000917 ( Main/Exploration ); précédent : 000916; suivant : 000918Use of Genetic Variation as Biomarkers for Alzheimer's Disease
Auteurs : Christiane Reitz [États-Unis] ; Richard Mayeux [États-Unis]Source :
- Annals of the New York Academy of SciencesBiomarkers in Brain Disease [ 0077-8923 ] ; 2009-10.
English descriptors
- KwdEn :
Abstract
Late‐onset Alzheimer's disease (LOAD) is the most common cause of late‐onset dementia in western societies. Despite remarkable achievements in human genetics throughout the years, in particular technological advances in gene mapping and in statistical methods that relate genetic variants to disease, to date only a small proportion of the genetic contribution to LOAD can be explained leaving several remaining genetic risk factors to be identified. A possible explanation for the difficulty in gene identification is that LOAD is a multifactorial complex disorder with both genetic and environmental components. Multiple genes with small effects each (“quantitative trait loci”[QTLs]) are likely to contribute to the quantitative traits associated with the disease, such as memory performance, amyloid/tau pathology, or hippocampal atrophy. The motivation for identifying the genetics of LOAD is clear. Not only could it shed light on disease pathogenesis, but it may also provide potential targets for effective treatment, screening, and prevention. Here, we review the usefulness of genetic variation as diagnostic tools and biomarkers in LOAD and discuss the potentials and difficulties researchers face in designing appropriate studies for gene discovery.
Url:
DOI: 10.1111/j.1749-6632.2009.04945.x
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Use of Genetic Variation as Biomarkers for Alzheimer's Disease</title>
<author><name sortKey="Reitz, Christiane" sort="Reitz, Christiane" uniqKey="Reitz C" first="Christiane" last="Reitz">Christiane Reitz</name>
</author>
<author><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:5D59722C34759D5320ACF4E2AB13D1BF4EFDEE5C</idno>
<date when="2009" year="2009">2009</date>
<idno type="doi">10.1111/j.1749-6632.2009.04945.x</idno>
<idno type="url">https://api.istex.fr/document/5D59722C34759D5320ACF4E2AB13D1BF4EFDEE5C/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">002881</idno>
<idno type="wicri:Area/Main/Curation">002533</idno>
<idno type="wicri:Area/Main/Exploration">000917</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Use of Genetic Variation as Biomarkers for Alzheimer's Disease</title>
<author><name sortKey="Reitz, Christiane" sort="Reitz, Christiane" uniqKey="Reitz C" first="Christiane" last="Reitz">Christiane Reitz</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Annals of the New York Academy of SciencesBiomarkers in Brain Disease</title>
<idno type="ISSN">0077-8923</idno>
<idno type="eISSN">1749-6632</idno>
<imprint><publisher>Blackwell Publishing Inc</publisher>
<pubPlace>Malden, USA</pubPlace>
<date type="published" when="2009-10">2009-10</date>
<biblScope unit="volume">1180</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="75">75</biblScope>
<biblScope unit="page" to="96">96</biblScope>
</imprint>
<idno type="ISSN">0077-8923</idno>
</series>
<idno type="istex">5D59722C34759D5320ACF4E2AB13D1BF4EFDEE5C</idno>
<idno type="DOI">10.1111/j.1749-6632.2009.04945.x</idno>
<idno type="ArticleID">NYAS4945</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0077-8923</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer's</term>
<term>biomarkers</term>
<term>genetics</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Late‐onset Alzheimer's disease (LOAD) is the most common cause of late‐onset dementia in western societies. Despite remarkable achievements in human genetics throughout the years, in particular technological advances in gene mapping and in statistical methods that relate genetic variants to disease, to date only a small proportion of the genetic contribution to LOAD can be explained leaving several remaining genetic risk factors to be identified. A possible explanation for the difficulty in gene identification is that LOAD is a multifactorial complex disorder with both genetic and environmental components. Multiple genes with small effects each (“quantitative trait loci”[QTLs]) are likely to contribute to the quantitative traits associated with the disease, such as memory performance, amyloid/tau pathology, or hippocampal atrophy. The motivation for identifying the genetics of LOAD is clear. Not only could it shed light on disease pathogenesis, but it may also provide potential targets for effective treatment, screening, and prevention. Here, we review the usefulness of genetic variation as diagnostic tools and biomarkers in LOAD and discuss the potentials and difficulties researchers face in designing appropriate studies for gene discovery.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Reitz, Christiane" sort="Reitz, Christiane" uniqKey="Reitz C" first="Christiane" last="Reitz">Christiane Reitz</name>
</region>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<name sortKey="Reitz, Christiane" sort="Reitz, Christiane" uniqKey="Reitz C" first="Christiane" last="Reitz">Christiane Reitz</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000917 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000917 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:5D59722C34759D5320ACF4E2AB13D1BF4EFDEE5C |texte= Use of Genetic Variation as Biomarkers for Alzheimer's Disease }}
This area was generated with Dilib version V0.6.23. |